Aswad -> RE: Bi-polar Mania on Mood Stablizers? (5/27/2007 12:43:47 AM)
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ORIGINAL: minnetar What do You think of the use of wellbutrin and zoloft in treating depression? Hi, minnetar. That would depend entirely on the patient in question. Personally, I'm not overjoyed at the idea, since other combinations give more opportunity to fine-tune the balance of the primary monoamines, but I have seen good results from unselective monoamine reuptake inhibition (triple reuptake inhibitor; whatever, they've got a million names for the smaller categories), so it's not out per se. The question is really what you're hoping to do with it, and for whom. If it's for a patient with a seizure disorder (e.g. tonic-clonic epilepsy), I would be hesitant to go for such a combination, as both lower the seizure threshold, and there are triple reuptake inhibitors who will give the same effect with less effect on the seizure threshold. If it's for someone trying to fix the sexual side-effects of the Zoloft, I'd say get bloodworks done first. If the testosterone is low, I'd supplement that (in women, Intrinsa might actually be a good idea even with normal testosterone, although you'd have to ask a GP or an endocrinologist about potential side-effects of that). If the prolactin is high, I'd use cabergoline instead of Wellbutrin; if not, I'd consider one of the other dopamine agonists, or possibly a DRI or stim, depending on the patient and the severity of the problem. If it's because the patient responds inadequately to either one by itself, I'd say there are probably significantly better choices out there, but it's hard to comment without knowing anything else. In short, if you want a useful answer, I will need more information. I'm fine with taking it via private messages if it's not a hypothetical question. Either way, you'd have to run this by the doc or pdoc treating the patient. I'm not a licenced mental health provider, I just try to help out all the other nutjobs like myself; even if I were, I wouldn't have the person's charts, etc., so please don't go out and override your doc based on what I've said here. [:D] Kind regards, Aswad.
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