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Psychiatry Medications (among others) - 11/4/2008 7:22:01 AM   
aravain


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Please keep in mind that I already have a doctor's appointment about this issue, but I'm posting more to get an opinion on if it's even viable, or if my medication has stopped working on its own.

Currently I'm prescribed a medication called Lamictal by my Psychiatrist. According to when we last increased the dosage (about a month ago) there's still room to move both up and down for it to be at a therapeutic dose.

Recently I've had to go see a specialist for what we thought was an allergic reaction, which turns out to be some sort of auto-immune reaction. Now, in addition to the Lamictal and my Blood Pressure medication, I'm also on Steroids (for another three weeks), and three different types of Anti-histamines (twice a day). According to the specialist I'll be on the anti-histamines for upwards of a year to try and 'smoke out' the hives.

It's working, too. The hives are less painful, numerous, and bothersome...

however my mental health has taken a peculiar run for the worse.

Rather than cycling (as is normal for me, even on my medication) I've been in a persistent depressed state for a little less than two weeks (I will have started the medications for this reaction three weeks ago tomorrow). On the 10-0-(-10) scale this has been consistently at a -8.

What's strange is that my cycling seems to have mostly stopped (for the first time since I was small).

A quick search yielded no results for me as to whether these medications might be affecting each other... but I thought it might be worth a shot to ask here to see if anyone has any experience with it. I'm hesitant to believe that the Lamictal has stopped working, because if it did I would be cycling much more violently than when it does work normally.
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RE: Psychiatry Medications (among others) - 11/4/2008 7:42:11 AM   
sirsholly


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I would advise you to call the psychiatrist asap. 

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RE: Psychiatry Medications (among others) - 11/4/2008 7:55:00 AM   
synningsub


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depending on which steroids youre taking, that could be the culprit... prednisone and many other steroids (frequently prescribed for hives and major allergic reactions) can have side effects including mood changes.. and many anti-histamines are also prescribed as anti-anxiety medications because they have those side effects.. they can also affect your moods by making you more sleepy and lethargic... these are just facts from my own life and may not be whats effecting you at all.. i'd be interested in what your doc has to say about it as well

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RE: Psychiatry Medications (among others) - 11/4/2008 8:22:38 AM   
SavageFaerie


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lamictal is actually an anti seziure medication, but th y have found that some anti seziures also work well for depression.
I was reading up on lamictal and one of the side effects you mentioned was a rash. In reading the below link it talks about how a rash can turn into a  SERIOUS  side effect.

I beleive this is the medication my sister takes in small doses, 1/2 tablet every 2 days I believe. She says it work wonder on her, but now that I think about it she has been have problems with rashes. I will have to mention that to her tonight

There is alot of information in the attached link, much of which talks about the rash and just how severe it can get. from reading it it seems like its not to be taken lightly regarding the rash, and if they have put you on steriods and several antihistimes I would really take a close look about changing medications to see if the rashes cease.

I would have your mental health dr, physician and your self perhaps conference, since the physical dr is doing the treating. 



http://www.lamictal.com/epilepsy/hcp/indications/faq.html

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RE: Psychiatry Medications (among others) - 11/4/2008 8:25:55 AM   
angelikaJ


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Lamictal has been implicated in auto-immune reactions and I have read that for some people antihistamines can cause depressive symptoms.
My person experience with steroids is that they can effect my moods.

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RE: Psychiatry Medications (among others) - 11/4/2008 8:33:34 AM   
aravain


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On the rash issue:

It's a very serious side effect, yes, that I don't have. My reaction was hives and I've been on Lamictal for nearly a year. That rash is an early-onset reaction to taking the Lamictal, and is usually centered on the trunk (not the extremities, which is where the hives were/are)

On the other responses:

I did not know that anti-histamines have a depressive quality... what with the sheer amount that I'm taking now, this could be the culprit. My 'baseline' is already lower than most peoples' (as in I level out at a -3 where most people level out at 0) so my suspicions may prove correct.

Thank you.

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RE: Psychiatry Medications (among others) - 11/4/2008 9:33:30 AM   
cagliostro


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There are other meds.  Thousands of them.  Well, maybe thousands.  But lots either way.  I had a doctor try to ram a psych med down my throat once.  I just told him that either he'd change it or I'd go to someone who would.  Don't take stuff you have an allergy to.  There's always another option.

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RE: Psychiatry Medications (among others) - 11/4/2008 10:15:32 AM   
aravain


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I... don't have an allergy to anything I'm taking...

I'm taking things to quell what we *thought* was an allergic reaction, but is *actually* an auto-immune reaction.

This is a relatively new development resulting from taking medications that are all, otherwise, working.

Where do you see that I'm allergic to something?

This also isn't the only medication I've been on for my mental disorder, and my doctor's very good about changing medication when/if it needs to be done. I make all the final decisions and she gives me the options. Two of the options are always the same: do nothing, stop medication, and then she usually includes a good deal of others if its needed.

If I had a bad doctor... I would get a good doctor.

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RE: Psychiatry Medications (among others) - 11/4/2008 10:49:44 AM   
RealSub58


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quote:

ORIGINAL: aravain
Currently I'm prescribed a medication called Lamictal by my Psychiatrist. According to when we last increased the dosage (about a month ago) there's still room to move both up and down for it to be at a therapeutic dose.


My sister DID have a reaction to lamictal and thus my skrink wont use it on me.The skrink that prescribed it to my sister did NOT take the precautions of increasing slowly as are the directions. There are reasons for this.  Within 4 hours she could not breath and was burning from the inside out with a syndrome called Stevens Johnson Shydrome.  She will have life long issues in regards to eyes, lungs and skin.  She lay in a burn unit for a month. This Syndrome is almost always the unspoken rare % and occurs if the med is not graded up and down properly.

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RE: Psychiatry Medications (among others) - 11/4/2008 10:52:04 AM   
xxblushesxx


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As to the cycling (or lack thereof) not going into that up and down state, may seem as a depressive state, when you are used to those highs and are not getting them. Are you sure you're not mistaking a level mindset, with a depressive mindset?

When I was in my 20's, I used to get hives...really bad...I used to get benadryl shots for them. Then all of a sudden, they stopped. I still don't know why. I always thought they were due to nerves.

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RE: Psychiatry Medications (among others) - 11/4/2008 11:00:08 AM   
RealSub58


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quote:

ORIGINAL: aravain
I did not know that anti-histamines have a depressive quality...

 
Most antihistamines cause drowsiness NOT "depressive effects."
 
Histamine is a substance in the body that stimulates the production of mucus and the dilation (widening) of blood vessels. Allergy sufferers recognize histamine's effects as a runny nose and swollen nasal passages. Antihistamines prevent histamine from binding to histamine (H1) receptors, thereby blocking the histamine reaction. They are different from the medications called histamine (H2) blockers that are used to treat peptic ulcer disease and heartburn.
 The older oral antihistamines, called first generation antihistamines, cause sedation in 20% to 35% of patients, but most patients build up tolerance to this side effect after a few days. The newer antihistamines, called second generation antihistamines, cause much less sedation and are longer acting than the earlier antihistamines. 
Drug Interactions

Some interactions between medications can be more severe than others. The best way for you to avoid harmful interactions is to tell your doctor and/or pharmacist what medications you are currently taking, including any over-the-counter products, vitamins, and herbals. For specific information on how the drugs interact and the severity of the interaction, please use our Drug Interactions Checker.
(The drug interaction checker is an awesome tool !!)To view specific side effect information, please use our Side Effect Checker.
http://www.drugdigest.org/DD/Comparison/NewComparison/0,10621,12-1,00.html

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RE: Psychiatry Medications (among others) - 11/4/2008 11:04:52 AM   
RealSub58


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quote:

ORIGINAL: aravain

I... don't have an allergy to anything I'm taking...

I'm taking things to quell what we *thought* was an allergic reaction, but is *actually* an auto-immune reaction.



I am sorry but antihistamine pharmacology is not for auto-immune reactions. There are meds for auto-immune reactions. aka steriods, which interfer with a whole ton of meds. Look prednisone up and you might be shocked!http://www.rxlist.com/deltasone-drug.htm


I am on way as I finish typing to find out why my new med of one week has weirded me out..........good luck at your appt.

< Message edited by RealSub58 -- 11/4/2008 11:06:47 AM >

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RE: Psychiatry Medications (among others) - 11/4/2008 11:11:17 AM   
sirsholly


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quote:

ORIGINAL: angelikaJ

My person experience with steroids is that they can effect my moods.



i take steroids when i get a flare-up of Rocky Mt Spotted Fever (damn tics...pain in the ass) and the steriods play hell with my moods/emotions and renal function.


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RE: Psychiatry Medications (among others) - 11/4/2008 11:44:25 AM   
LadyHibiscus


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I am one of the very lucky ones who can take prednisone with no bad effects (I love my hives, really I do...)  but they are nasty things.  Call NOW about getting an adjustment, why suffer needlessly?

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RE: Psychiatry Medications (among others) - 11/4/2008 1:08:49 PM   
aravain


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I'm really sorry for your sister :( Any family history with the reaction is a very big no-no for people to prescribed, so I'm glad that your doctor was smart enough to know that! It sucks that her doctor didn't go up slowly like you're supposed to... I was actually aclimated to lamictal in the hospital, so my rate was pretty quick (50mg one day, 150mg the next, smack dab to 250mg the third day) but I had no reaction and was under CONSTANT surveillance, which is why they were comfortable with it. Most lamictal packs start out with you taking 15 or 25 for a week and work up steadily, though, I believe.

To xxblushesxx: Yes, I'm sure. Knowing it was a product of intensive outpatient therapy. The 'baseline' for me (that is, where my cycles center, and at what point I'm in a 'normal' non-extreme state) is just actually a more depressive state than for 'ordinary' people. Also, my manias are terrible... quite usually dysphoric or at the very least disturbing, so I enjoy them less than I do depressions. But this has been said to me by an actual psychiatrist and psychologist team.

To RealSub58 (again): Well damn. Guess it's back to the drawing board on possible causes for this :( However, you're wrong on the usage. This auto-immune reaction is creating the histamines which are creating the hives. It's a relatively new-understood phenomena, according to two of my (now three) doctors, which is affecting a large portion of the population (I believe he said something like 11%). I hope my appointment goes off without a hitch and this can be fixed with a simple dose increase or decrease, or better yet no change!

To sirsholly: Interesting... :( I've never been on steroids before, so maybe the Prednisone is the overlying cause. At least I'll be off of it soon and my dose is going down steadily.

To LadyHibiscus: Getting an adjustment on what? The steroids and anti-histamines are doing their jobs just fine, and my psychiatrist won't adjust prescriptions without seeing me (which is this Thursday). Since it's not life-threatening, but simply life-agravating, I don't think it's important enough for me to go to the hospital to get a prescription there. The prednisone dosage is going down steadily anyways, if that's what you mean, not staying even, so I don't really have to worry too much longer if it IS the cause.

Thank you again everyone :)

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RE: Psychiatry Medications (among others) - 11/4/2008 3:56:41 PM   
angelikaJ


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Depression and antihistamines:
http://www.healthboards.com/boards/archive/index.php/t-12823.html

http://answers.yahoo.com/question/index?qid=20071226003202AAp0RnH

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RE: Psychiatry Medications (among others) - 11/4/2008 7:25:48 PM   
celticlord2112


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quote:

Recently I've had to go see a specialist for what we thought was an allergic reaction, which turns out to be some sort of auto-immune reaction. Now, in addition to the Lamictal and my Blood Pressure medication, I'm also on Steroids (for another three weeks), and three different types of Anti-histamines (twice a day). According to the specialist I'll be on the anti-histamines for upwards of a year to try and 'smoke out' the hives.

You need to contact your psychiatrist ASAP and review your Lamictal regimen in light of the other medications you are now taking.  Lamictal, an anti-hypertensive, steroids, and three different antihistamines is quite the drug cocktail--the potential for drug interactions is at the very least significant.


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RE: Psychiatry Medications (among others) - 11/4/2008 9:16:37 PM   
aravain


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Which is why I have an appointment with my psychiatrist...

She only works two days a week, and there were no adverse effects beyond this, which wasn't so bad that I needed to go to the emergency room, which is why we opted for a normal appointment... instead of me going to a local hospital.

I do live on a college campus, and she IS a member of the college counseling services, which is the only way that I can get covered visits with a dedicated psychiatrist (plus, even if they weren't covered, since I'm a student they're free). So... it's not like I can schedule a next-day appointment, I usually have to do it two weeks in advance, especially since I can only go on one of the two days a week she works.

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RE: Psychiatry Medications (among others) - 11/10/2008 10:17:48 PM   
DesFIP


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Lamictal should stop the cycling. That's a good thing. The depressive state might lift as you increase the dosage or add another medication.

However the worry here is the rash, that's a sign of Stevens-Johnson Disorder and it is potentially life threatening. Call whoever is treating you for the rash and insist they evaluate you for Stevens Johnson. If you have it, then you need to come off the Lamictal permanently.

The odds of Steven Johnson occur in the first two weeks of taking it, or the first two weeks after raising the dosage. It took my daughter six months to get to the level she's now at, raising it very slowly each time and waiting to ensure no rash.

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RE: Psychiatry Medications (among others) - 11/11/2008 6:19:32 AM   
chamberqueen


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You could consider calling a poison control hot line.  I used to do this when my daughter was young and I was concerned that there might be an adverse reaction between medications. 

Your pharmacist should have the same information available.  Either source will be able to tell you whether you need to make a change immediately or whether it is safe to wait until your scheduled appointment.


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