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shivermetimbers -> RE: Why do injections hurt so bad and why does the arm stay sore for days and days? (12/16/2008 11:02:14 PM)
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Many injections, the medication is not isotonic, and irritates the nerves, giving the burning sensation. Certain medications cause an antigen response by the body, resulting in inflammation and discomfort, quite common with vaccines. Some medications are not quite liquid (as anyone who ever received a gamma globulin shot in the ass in the military knows) and take time for the body to absorb. The injection itself should be administered swiftly, like throwing a dart, which practically eliminates any feeling of the puncture. Needles hitting the bone are painful simply because lance has been damaged, even if microscopically, and when pulled out causes trauma and inflammation. Bones themselves are not innervated, so the pain isn't actually from the strike of the bone, however, you know that it HAS hit the bone, and it's a psychologically unappealing feel. Using too large of a gauge of needle causes trauma. Many intramuscular shots end up never being deposited into the muscle tissue, and those types of medication are very irritating if not delivered properly. Subcutaneous injections into areas with little adipose tissue also are quite irritating.
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