Hippiekinkster -> RE: urine consumption & drugs (7/20/2011 6:02:24 PM)
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ORIGINAL: Aswad The point about metabolism is key. Some drugs are extensively metabolized before being excreted, and some tests are specifically looking for the metabolic end-products. If there is no renal excretion of the unchanged drug, then the end-product will generally be filtered out rapidly and effectively, if it is even absorbed in the first place. However, the person taking the drug will keep producing end-products for the duration of the drug in the system. And, as pointed out, if the drug is excreted in its original form, then these end-products will be produced in the recipient's body, which causes them to be detectable in the urine for far longer than if absorbed in their pre-metabolized state. With all the usual disclaimers, I would point out that dronabinol is not excreted in the kidneys. Instead, its metabolites are excreted. Since it is highly lipid soluble and has a highly variable half-life with a long terminal half-life, a user of dronabinol will pass these metabolites in the urine at measurable levels for a long time. However, the receiver will be absorbing a limited fraction of the metabolites, and these will be rapidly excreted from the body. They do not persist for a significant time, and after the first visit to the bathroom, what little remains will be heavily diluted if adequate hydration is maintained (which is critical with urine consumption anyway). So, long story short, it could be detected after a short time, but a bladderful on friday or saturday shouldn't turn up on monday. It is still better to have the paperwork on hand, though, and to use a home test kit (or, better yet, get a proper analysis of both your samples). This applies to dronabinol only, though. And, as noted, with all the caveats. If anyone is curious about the right way to test, it's bringing an ordinary urine sample to a lab with an NMR and paying them to check for the drug one is concerned about. Universities are usually cheaper, if you can find someone with the time to spare for it, but the quality is going to depend significantly on the experience of the operator. Gas chromatography in tandem with a mass spectrometer is the gold standard for drug identification, including their metabolites. While nuclear magnetic resonance software packages are available which can identify a large number of molecules of interest, including metabolites, they are not, to my knowledge, in wide use.
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