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Aids epidemic nearing its end? - 7/22/2012 6:27:30 PM   
JstAnotherSub


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Status: offline 		Aids epidemic nearing its end?

I sincerely hope that everything possible is done to make this a reality.
And what a brave young lady!

In this week’s Journal of the American Medical Association, Fauci and his colleague Gregory Folkers outline recent scientific advances in AIDS research, and the way forward for implementing these tools in working towards an AIDS-free generation.

Among the tools proven effective against AIDS are, first, effective combination antiretroviral therapy. These medications can save the lives of people living with HIV, as well as prevent transmission to sexual partners and from mother to child. Second, male circumcision has been shown to decrease the risk of a heterosexual man contracting HIV. And finally, a daily medication can now be used to prevent contracting HIV, termed “pre-exposure prophylaxis” and recently approved by the Food and Drug Administration.




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RE: Aids epidemic nearing its end? - 7/22/2012 11:18:37 PM   
Thaz


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Status: offline 		AIDS gone in Europe and North America. Entirely possible.

Latin America? Maybe. The catholic church needs to seriously get a grip if so.

Africa? Various US funded NGO's need to seriously re-think their policies if so. Or get out spent by Bill Gates and co.


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RE: Aids epidemic nearing its end? - 7/23/2012 6:10:49 AM   
kalikshama


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Status: offline 		Is this man proof of Aids cure?

London - Aids researchers believe the time may have come to think the unthinkable: a growing body of expert opinion believes a cure for HIV infection is no longer a scientific impossibility but a realistic goal that scientists could reach in the very near future.

A scientist who shared a Nobel prize for the discovery of human immunodeficiency virus (HIV) has now added her voice to those who believe it is possible to cure a viral infection that until now has been considered life-long, chronic and, although treatable, ultimately incurable.

Françoise Barré-Sinoussi, who first reported the discovery of the Aids virus in 1983 with her colleague Luc Montagnier of the Pasteur Institute in Paris, is expected later today in Washington to say that talk of a cure for HIV should no longer be a taboo subject for Aids researchers.

She will cite the case of the “Berlin Patient”, an American gay man called Timothy Brown who received a bone marrow transplant in 2007 while a student in Germany. The transplant was undertaken to treat a type of blood cancer but in the process it also apparently cured Mr Brown of his HIV infection.

Five years after his transplant, he continues to be free of HIV despite having given up his anti-viral drugs. It is still not clear to scientists why Mr Brown has managed to shrug off his chronic HIV infection so effectively.

Read more: http://www.iol.co.za/scitech/science/news/is-this-man-proof-of-aids-cure-1.1345769#.UA1I_rSe5Hd

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RE: Aids epidemic nearing its end? - 7/23/2012 6:13:45 AM   
kalikshama


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Status: offline 		Stem cell cure for HIV to enter human trials

A team of Australian scientists is advancing towards a cure for conditions including HIV and diabetes using stem cells.

Professor Alan Trounson, a world-renowned Australian stem cell expert and head of the California Institute of Regenerative Medicine, says their work towards HIV cure is about to progress to human trials.


He said if the trials were successful further research would be needed to modify the technology so it could be affordably used where it is needed most, in Africa.

"I want the HIV work to go globally because it shouldn't be restricted to patients in Western (countries)," the Herald Sun quoted Prof Trounson, the former director of Monash Immunology and Stem Cell Laboratories in Melbourne, as saying.

"We're going to have to modify some of that further research to get it into a suitable treatment that we can use in Africa.

I'm very hopeful that the industry will do that. We have to try and make these as available to people as possible," he stated.

Prof Trounson said the HIV research uses blood stem cells to mimic a gene mutation found in a small proportion of the population who are immune to the virus.

The approach is based on the case of an American, known as the Berlin patient, who was cured of HIV after receiving a life-saving bone marrow transplant to treat leukaemia from a donor who carried the HIV-immune mutation.

The institute is also using embryonic stem cells to try and cure blindness caused by macular degeneration and to develop insulin-producing cells for type 1 diabetes sufferers, Prof Trounson said.

Meanwhile, new drug treatments for cancer have been developed using stem cells, which are now being tested on patients, said Prof Trounson.

However, even if the trials are successful it could be six to seven years before those treatments are widely available to patients, he said.

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RE: Aids epidemic nearing its end? - 7/23/2012 7:22:10 AM   
Rule


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Status: offline 		Do google "suspicious deaths" microbiologists aids.

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RE: Aids epidemic nearing its end? - 7/24/2012 7:36:39 AM   
kiwisub12


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Status: offline 		Actually, Rule is correct - if we let all humans with genetically transmitted, and infectious diseases die, sooner or later those diseases would no longer occur in the general public.

However, the cost to humanity would be incalculable. How would watching your child die of diabetes, when you know there is a drug that could dramatically increase his life span affect a parent? How would the dehumanization affect the way that people interact with each other?

I think the Nazis had a program that pretty much was along the same lines, and they didn't turn out so well.

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RE: Aids epidemic nearing its end? - 7/24/2012 10:59:55 AM   
Hillwilliam


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quote:

ORIGINAL: kiwisub12

Actually, Rule is correct - if we let all humans with genetically transmitted, and infectious diseases die, sooner or later those diseases would no longer occur in the general public.

However, the cost to humanity would be incalculable. How would watching your child die of diabetes, when you know there is a drug that could dramatically increase his life span affect a parent? How would the dehumanization affect the way that people interact with each other?

I think the Nazis had a program that pretty much was along the same lines, and they didn't turn out so well.

Actually, rule is quite incorrect. Most, if not all, lethal genetic diseases are recessives. This means that someone can be a carrier and totally unaffected. The only way the allele expresses itself is if both parents are carriers. Then, typically, one in 4 of the offspring show the condition. In the case of sex linked diseases, half of the males will show the disease.
The important thing to remember is that carriers will still pass the allele to a significant portion of their offspring ensuring that the allele will never be eliminated from the population.
There are also some genetic diseases that, while frequently lethal in the homozygous form, are advantageous in the heterozogous. An example is the sicle cell trait which confers immunity to malaria in the heterozygous form.

Infectuous diseases cannot be killed off either. Many viral diseases just slip over to an animal if no human hosts are available. They remain there until such time as human hosts become available again. Bacterial diseases can either live in an animal host or encapsulate into spore form which can remain viable and lethal for years or even centuries. anthrax is a good example of the latter type.

Some folks should just leave the biology and genetics to those who actually have a semblance of education in the area.

< Message edited by Hillwilliam -- 7/24/2012 11:01:00 AM >

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RE: Aids epidemic nearing its end? - 7/24/2012 11:44:31 AM   
VideoAdminTheta


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Status: offline 		I have removed the majority of posts on this thread, but believe it worth my efforts to continue this topic for discussion, rather than to remove the whole thread. Please consider Terms of Service as you continue contributing to the thread.

In the process of having to remove so much, I have left some posts that contributed to the discussion and hope that it isn’t confusing without the flow of what was said before that could not remain.

Thank you for your cooperation and enjoy the thread!

Edit, Cannot leave out words!

< Message edited by VideoAdminTheta -- 7/24/2012 12:09:43 PM >

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RE: Aids epidemic nearing its end? - 7/24/2012 12:04:07 PM   
kalikshama


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Status: offline 		Thanks Theta!

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RE: Aids epidemic nearing its end? - 7/24/2012 7:02:28 PM   
dcnovice


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Status: offline 		FR

I just want to be there.

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RE: Aids epidemic nearing its end? - 7/24/2012 7:12:32 PM   
hausboy


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quote:

ORIGINAL: dcnovice

FR

I just want to be there.


me too DC me too.
I buried way too many brilliant, beautiful, bright souls.

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RE: Aids epidemic nearing its end? - 7/27/2012 7:30:22 AM   
LadyConstanze


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Status: offline 		Here's an interesting article

Two more men with HIV now virus-free. Is this a cure?

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RE: Aids epidemic nearing its end? - 7/27/2012 9:06:14 AM   
MissKittyDeVine


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Status: offline 		If/when a cure is developed, though, how accessible will it be? Big Pharma sure as hell won´t be giving it away...

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RE: Aids epidemic nearing its end? - 7/27/2012 2:53:07 PM   
Rule


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quote:

ORIGINAL: kiwisub12
Actually, Rule is correct

I thank you for your support, but you mis-understood me.

quote:

ORIGINAL: kiwisub12
if we let all humans with genetically transmitted, and infectious diseases die, sooner or later those diseases would no longer occur in the general public.

I have never proposed that.
In any case it is unlikely that diseases will be eradicated. Even the small pox virus still exists in a few laboratories. Besides, I am against the eradication of species, including bacteria and virusses.

quote:

ORIGINAL: kiwisub12
However, the cost to humanity would be incalculable. How would watching your child die of diabetes, when you know there is a drug that could dramatically increase his life span affect a parent?

Diabetes is neither inherited nor as a condition infectious. I have never proposed with-holding medication from a diabetes patient.

quote:

ORIGINAL: kiwisub12
How would the dehumanization affect the way that people interact with each other?

I have never proposed dehumanizing anyone.

quote:

ORIGINAL: kiwisub12
I think the Nazis had a program that pretty much was along the same lines, and they didn't turn out so well.

I do not know about that. However, the (foreign) high IQ sociopaths who planned the Second World War and who pulled their strings by definition are dimwitted and lacked someone like me to counsel them and to obey.


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RE: Aids epidemic nearing its end? - 7/27/2012 3:15:24 PM   
Rule


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quote:

ORIGINAL: Hillwilliam
Actually, Rule is quite incorrect.

Oh?

quote:

ORIGINAL: Hillwilliam
Most, if not all, lethal genetic diseases are recessives. This means that someone can be a carrier and totally unaffected. The only way the allele expresses itself is if both parents are carriers. Then, typically, one in 4 of the offspring show the condition. In the case of sex linked diseases, half of the males will show the disease.
The important thing to remember is that carriers will still pass the allele to a significant portion of their offspring ensuring that the allele will never be eliminated from the population.

Quite.
It indeed is unlikely that deleterious alleles will ever all be eliminated from the population.
However, considering that the frequency of deleterious alleles in non-cricumcising populations of Christian European descend are six times lower than in populations that have been practising circumcision for many generations, it is clear that the frequencies of such deleterious alleles in the gene pool of a population can be drastically reduced. The only requirement to enable this reduction, is to not circumcise.

quote:

ORIGINAL: Hillwilliam
There are also some genetic diseases that, while frequently lethal in the homozygous form, are advantageous in the heterozogous. An example is the sicle cell trait which confers immunity to malaria in the heterozygous form.

Quite. One of my old hypotheses is that if the frequency of a deleterious allele is higher than 1 in a thousand (if I remember correctly), that such an allele may confer such an advantage. Whereas if it is smaller, it confers no such advantage.

Also, a deleterious allele (or the gene that codes for another protein that it associates with) might - hypothetically - experience another mutation that improves upon the wildtype normal allele. Unlikely, but possible.

quote:

ORIGINAL: Hillwilliam
Some folks should just leave the biology and genetics to those who actually have a semblance of education in the area.

Pff. There are not a lot of people who can do better in biology examinations than me, provided that I have had some time to study the subject(s).

< Message edited by Rule -- 7/27/2012 3:19:11 PM >

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